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Evidence is increasing that every addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both after they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err to the side of caution and let the FDA do its job and demand some research be done so your public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on his or her medications.

Researchers discovered that participants taking this drug for the year, lost weight within a month and have kept the weight off during the entire 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, which might make them more efficient and safer.

Combo-pilling may be the newest fad or also the newest ahead under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular may be the fact that by right now there are not any long term prescription weight loss supplements that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise hypertension and heartbeat, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

"This will be the first drug I'm alert to that targets the two appetite and reward centres within the brain," he was quoted saying.