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Evidence is increasing that every addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This the main problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both whenever they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight naturally can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people who go through it you should err along the side of caution and allow FDA do its job and demand some investigation be done so that the public recognizes the side effects and hazards of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say everything to keep people on the medications.

Researchers found that participants investing in this drug for the year, lost weight within four weeks and have kept the extra weight off during the entire 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, that might make them more potent and safer.

Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that by right now there aren't long term prescription diet pills that have been authorized by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug also can raise blood pressure level and pulse rate, and shouldn't be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients with a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.

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