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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) in excess of 27, given that they also suffer from weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to quitting smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% as opposed to participants who were given placebos) during a 12- month period, while a different study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err on the side of caution and permit the FDA do its job and demand some investigation be done so your public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on his or her medications.

Researchers found out that participants investing in this drug for any year, lost weight within four weeks and have kept the body weight off during the entire 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of several active ingredient, which might make them more efficient and safer.

Combo-pilling may be the newest fad or also the newest to come under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is now popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug also can raise blood pressure and pulse rate, and must not be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure level, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

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